The sides drew 1-1 in their rain-affected three-match Twenty20 series but India have been dealt a blow ahead of the opening Test against the Proteas next week as Bumrah has been ruled out.
The 25-year-old has suffered a minor stress fracture in his lower back, the Board of Control for Cricket in India said in a short statement on Twitter, and he has been replaced by Umesh Yadav.
Bumrah has enjoyed an outstanding start to life in Test cricket since his January 2018 debut.
He has played 12 Tests and collected 62 wickets, including an impressive five five-wicket hauls, taking a hat-trick in his last match against West Indies in August.
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